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Funded Project Details - FY2021

Project Number:

Title: TGFβ and Smad Signaling Components in Esophageal Adenocarcinoma
Principal Investigator:

Andrew Blum

Location: Cleveland, OH
Congressional District Code: 11
Research Service: Clinical Science R&D
Project Period: February 2020 - January 2025
FY 2021 Funding Amount: $374,738
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Esophageal adenocarcinoma (EAC) is a highly fatal cancer with 5-year survival under 20%. Alarmingly, the incidence of cancer of the esophagus has increased significantly over the past 30 years. EAC arises from a known precursor lesion, termed Barrett's esophagus (BE), that can be easily recognized at endoscopy. However, current clinical strategies of screening and surveillance are inadequate and EAC diagnosis often occurs at advanced and unresectable stages of the disease. Veterans are increased...

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