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Funded Project Details - FY2021

Project Number:

Title: Development of new drugs for Toxoplasma by advancing hits from the Global Health Chemical Diversity Library
Principal Investigator:

Phil Alday

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: January 2020 - December 2024
FY 2021 Funding Amount: $289,825
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Toxoplasma gondii is a prolific eukaryotic parasite that is widely distributed throughout the world. Infection with T. gondii can cause severe and potentially fatal brain and eye disease, especially in immunocompromised individuals. Worldwide, T. gondii is also a leading infectious cause of blindness in otherwise healthy individuals. The current first-line therapy for T. gondii is a combination of the drugs pyrimethamine and sulfadiazine, but this regimen suffers from a number of shortcomings. The...

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