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Project Number: | I01BX001232-11 |
| Title: | SUMOylation of Cu transport protein Atox1 in Atherosclerosis |
| Principal Investigator: | Tohru Fukai |
| Location: | Augusta, GA |
| Congressional District Code: | 10 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2020 - March 2024 |
| FY 2021 Funding Amount: | $244,608 |
| Total Award Amount (all years): |
$1,151,232 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The aim of this grant is to demonstrate a novel redox-dependent SUMOylation of Copper (Cu) chaperone “Antioxidant-1 (Atox1)” as a key switch to promote Cu-dependent transcription factor function linked to vascular inflammation and atherosclerosis. Cu is implicated in inflammation and atherosclerosis with unknown mechanism. We previously found that Cu-chaperone Atox1 functions as a Cu-dependent transcription factor for p47phox to promote reactive oxygen species (ROS)-dependent inflammatory respon... |