Control of Circuit Hyperexcitability by Endogenous Opioids in Epilepsy
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Biomedical Laboratory R&D
April 2020 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Epilepsy is a devastating neurologic condition that affects about 2 million Americans and is often resistant to medical treatment. Animal studies have demonstrated that epilepsy is associated with compensatory changes in the brain, which includes the aberrant rewiring of neuronal circuits. In particular, epilepsy is associated with altered connectivity in the hippocampus, a region of the brain that is frequently the focal point for the initiation of seizures. One particular hippocampal circuit r...