Impact of Inflammatory Pathway in Tumor Stroma on Pancreatic Cancer Growth
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Biomedical Laboratory R&D
April 2020 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Despite recent advances, pancreatic cancer patients continue to have dismal outcomes thereby underscoring the need for development of new therapeutic strategies. Recently, there has been a resurgence in understanding the role played by stroma in supporting tumor growth and the stroma- cancer cell cross talk continues to be a promising anti-cancer target. Previous research has shown that NFκB, the master regulator of inflammation, is overexpressed in various cancer cells, and its deletion in the...