The Multiple Roles of Lysyl Oxidase in Arteriovenous Fistula Failure
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Biomedical Laboratory R&D
April 2020 -
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
More than 14 000 enrolled veterans depend on an arteriovenous (A-V) fistula or other type of vascular access to receive hemodialysis and prolong their lives. The transformation of a vein to a fistula is one of the most intriguing processes in vascular biology. The desired scenario is that the fistula matures becoming a larger vessel with increased luminal area and a thicker wall. Unfortunately, A-V fistulas frequently fail (~40%) because venous stenosis compromises blood flow. We recently discov...