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Funded Project Details - FY2021




Project Number:

I01BX004444-01A2
Title: Control of beta cell identity by the mitochondrial life cycle
Principal Investigator:

Scott A Soleimanpour

Location: Ann Arbor, MI
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $134,375
Total Award Amount
(all years):
$635,150
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Diabetes results from insufficient functional pancreatic β-cell mass to meet peripheral insulin demands. β-cell failure can occur in T2D due to loss of β-cell identity or de-differentiation, with recent studies suggesting that loss of the mitochondrial gene expression program heralds the immature β-cell state. β-cells rely upon mitochondrial respiration to generate the energy necessary for the metabolic demands of insulin biosynthesis, processing, and secretion. Indeed, defects in mitochondrial...



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