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Project Number: | I01BX002624-05A1 |
| Title: | Role of host sphingolipids against fungal infections |
| Principal Investigator: | Maurizio Del Poeta |
| Location: | Northport, NY |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2020 - December 2023 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$791,225 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: ABSTRACT The goal of this project is to study the role and mechanisms by which sphingomyelin synthases (Sms1 and Sms2) are involved in controlling the infection caused by the pathogenic fungus Cryptococcus neoformans (Cn). Our laboratory has pioneered studies dealing with the role of fungal sphingolipids in the regulation of infectious diseases. In addition to studying fungal sphingolipids, we have recently discovered that certain host sphingolipids play a key role in controlling the immune re... |