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Project Number: | I01BX004468-01A1 |
| Title: | Regulation of Muscle Mitochondrial Protein Homeostasis by Insulin/IGF-1/FoxO Signaling |
| Principal Investigator: | Brian O'Neill |
| Location: | Iowa City, IA |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2020 - December 2023 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Insulin resistance and uncontrolled diabetes are very common among Veterans and lead to decreased muscle strength, contributing to impaired recovery from illness and other disease-related morbidity. Indeed, patients with diabetes recover strength slower after major surgery than non-diabetic patients. These changes are associated with decreased muscle mitochondrial energy production, but the signals that control mitochondrial metabolism in muscle during diabetes remain incompletely understood. We... |