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Project Number: | I01BX004237-01A2 |
| Title: | Microglial Phagocytosis of Dendritic Spines in Veterans with Schizophrenia |
| Principal Investigator: | David Volk |
| Location: | Pittsburgh, PA |
| Congressional District Code: | 14 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2020 - March 2024 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$660,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Schizophrenia (SZ) is a severe and chronic psychiatric illness characterized by cognitive dysfunction. SZ has a higher prevalence in Veterans and is associated with increased disability and mortality in Veterans. Genome-wide association studies have identified variants of microglia-related genes as risk factors for SZ. How such genetic factors might be manifest as molecular alterations in microglia in SZ is not clear. Understanding microglial function in SZ is important because microglia are inv... |