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Project Number: | I01BX001174-09 |
| Title: | Mechanisms of Liver Injury |
| Principal Investigator: | Chandrashekhar R. Gandhi |
| Location: | Cincinnati, OH |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2020 - December 2023 |
| FY 2021 Funding Amount: | $272,375 |
| Total Award Amount (all years): |
$1,241,631 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Acute liver failure (ALF) is a devastating condition with high mortality (60-80%), and liver transplantation is the only life-saving option for ALF due to the lack of early diagnostic indicator(s) and effective pharmacologic treatment. Incidence of drug-induced (acetaminophen [APAP] being most common) hepatotoxicity is very high in general and in particular VA populations, and accounts for about 15% of the liver transplants. Therefore, precise knowledge of the mechanisms and diagnostic indicator... |