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Project Number: | I21RX003324-01 |
| Title: | Neuron-targeted caveolin-1 as a gene therapy for ALS |
| Principal Investigator: | Brian P. Head |
| Location: | San Diego, CA |
| Congressional District Code: | 52 |
| Research Service: | Rehabilitation R&D |
| Project Period: | January 2020 - December 2021 |
| FY 2021 Funding Amount: | $100,000 |
| Total Award Amount (all years): |
$200,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease resulting from loss of both upper and lower motor neurons in the brain and spinal cord. ALS symptoms include diffuse muscle weakness, muscle atrophy, spasticity and hyperreflexia (upper), paralysis (lower), and 2-5 year life expectancy. One approach to combat ALS is delivery of neurotrophic factors to protect damaged motor neurons, but this is dependent upon expression and proper subcellular localization of key n... |