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Project Number: | I01CX001933-01 |
| Title: | Cross-comparison of patient-derived xenografts and derivative organoids and cell lines for translational research in hepatocellular carcinoma |
| Principal Investigator: | David E. Kaplan |
| Location: | Philadelphia, PA |
| Congressional District Code: | 3 |
| Research Service: | Clinical Science R&D |
| Project Period: | January 2020 - December 2023 |
| FY 2021 Funding Amount: | $165,000 |
| Total Award Amount (all years): |
$699,939 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: PROJECT SUMMARY Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide with more than 745,000 fatalities in 2012 alone. The majority of patients with HCC present with unresectable disease at diagnosis and a life expectancy of less than 20 months, with only 15% of these patients surviving more than one year after diagnosis. This dismal prognosis underscores the limited therapeutic options for these patients. HCC is a notoriously chemoresistant malignancy and... |