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Project Number: | I01BX004313-01A1 |
| Title: | CTBI: Tauopathy in Mice and Human: Effects of Open-Field Low-Intensity Blast on Brain Ultrastructure and Outcomes in Mild Traumatic Brain Injury |
| Principal Investigator: | Zezong Gu |
| Location: | Columbia, MO |
| Congressional District Code: | 4 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2019 - September 2023 |
| FY 2021 Funding Amount: | $308,584 |
| Total Award Amount (all years): |
$1,370,674 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Project Summery Overall Research Strategy: Traumatic brain injury (TBI) from open-field blast or repetitive mild head impact to human tau transgenic mice will induce Alzheimer-relevant, tau-dependent pathology, that can be rescued by suppression of tau expression or tau aggregation inhibitors. Blast-induced tau-related pathological changes will be analyzed in brains from veterans and mice exposed to blast, and biomarkers for TBI, chronic traumatic en- cephalopathy (CTE) and Alzheimer-pathology w... |