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Project Number: | I21BX004612-01 |
| Title: | p75NTR ligands for ALS therapy |
| Principal Investigator: | Stephen M. Massa |
| Location: | San Francisco, CA |
| Congressional District Code: | 12 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2019 - June 2021 |
| FY 2021 Funding Amount: | $56,250 |
| Total Award Amount (all years): |
$175,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Amyotrophic lateral sclerosis (ALS) is a progressive, disabling and ultimately fatal neuromuscular disease which has increased incidence in veterans and upon which currently available therapies have only nominal effects. The overall goal of this proposal is to determine whether a small molecule modulator of the p75 neurotrophin receptor (p75NTR) will inhibit progression of pathology and improve outcomes in ALS. Impaired neurotrophin-mediated signaling and activation of p75NTR-associated death me... |