Impact of Sterilizing and Non-sterilizing Antibiotics on M. tuberculosis rRNA Synthesis
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Biomedical Laboratory R&D
October 2019 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Tuberculosis (TB) is an important health concern for veterans and service members who serve in TB-endemic countries. There is an urgent need for new shorter TB treatment. The length of treatment required to prevent relapse is determined by the effectiveness of drugs during the long “sterilizing” phase of treatment that follows early bactericidal killing. Different tissue micro-environments harbor M. tuberculosis (Mtb) populations with different replication rates that respond differently to drug...