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Funded Project Details - FY2021




Project Number:

I01BX004289-01A2
Title: Mechanisms of Alveolar Mitochondrial Damage and Resolution in Pneumonia
Principal Investigator:

Karen Welty-Wolf

Location: Durham, NC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$651,800
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Abstract Acute Lung Injury (ALI) afflicts ~200,000 people in the United States every year and >30% of these patients die. ALI is characterized by severe alveolar inflammation caused primarily by pneumonia, sepsis, and aspiration, causing loss of alveolar type I epithelial cells and failure of alveolar barrier function. New treatments for ALI have failed, partly because of the injury heterogeneity and uncertainty about appropriate drug targets. Delayed resolution of ALI is related to alveolar ep...



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