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Project Number: | I01BX000168-10A1 |
| Title: | Maladaptive Remodeling in Aging Myocardium |
| Principal Investigator: | Francis G. Spinale |
| Location: | Columbia, SC |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2019 - March 2023 |
| FY 2021 Funding Amount: | $119,861 |
| Total Award Amount (all years): |
$783,328 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Left ventricular (LV) remodeling is a summation of cellular and extracellular matrix (ECM) events, which invariably occur following a myocardial infarction (MI) and is an important predictor of clinical outcomes. Increased inductions of the ECM proteolytic enzymes, the matrix metalloproteinases (MMPs), occur in the early and late phases of post-MI remodeling. While MMP inhibition remains an important therapeutic target in the context of post-MI remodeling, systemic delivery of broad spectrum pha... |