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Project Number: | I01BX004272-01A2 |
| Title: | Signals controlling tissues homeostasis in the ovary |
| Principal Investigator: | John S. Davis |
| Location: | Omaha, NE |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2019 - September 2023 |
| FY 2021 Funding Amount: | $254,200 |
| Total Award Amount (all years): |
$807,400 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Recent developments in other fields of research have shed light on an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis, and stem cell self-renewal. This pathway is called the Hippo signaling pathway and disrupting the Hippo pathway results in the loss of tissue homeostasis and contributes to many human diseases. Despite extensive study of the Hippo pathway in the past decade, the exact nature of extracellular signals and membrane receptors reg... |