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Project Number: | I01BX004665-01 |
| Title: | Targeting Kinases in Novel Preclinical Models of Adrenocortical Carcinoma |
| Principal Investigator: | Margaret E. Wierman |
| Location: | Denver, CO |
| Congressional District Code: | 6 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2019 - June 2023 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Adrenocortical carcinoma (ACC) is a deadly malignancy with survival <35% at 5 years and occurs across the lifespan afflicting both young and older male and female veterans. Current treatment options of surgery, mitotane and chemotherapy are inadequate. The mechanisms underlying ACC tumorigenesis are poorly understood. Patients with genetic syndromes have an increased risk of ACC; however, the majority of cases are sporadic. To date, no pathway has been successfully targeted in ACC in clinical tr... |