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Project Number: | I01BX000505-09 |
| Title: | Neutrophil Polarization Following Myocardial Infarction |
| Principal Investigator: | Merry L Lindsey |
| Location: | Omaha, NE |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2019 - June 2023 |
| FY 2021 Funding Amount: | $247,422 |
| Total Award Amount (all years): |
$1,105,835 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Abstract About one in four myocardial infarction (MI) patients progress to develop congestive heart failure, which has a 5-year mortality rate of 50%. The goal of this project is to understand post-MI roles of neutrophils by establishing how this cell type transitions in phenotype during wound healing spanning from inflammation to repair. We hypothesize that neutrophils undergo a temporal phenotype evolution that includes influencing post-MI inflammation resolution and ECM organization. Specifi... |