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Project Number: | I01BX004639-01 |
| Title: | HDL as a therapeutic target for sepsis |
| Principal Investigator: | Xiang-An Li |
| Location: | Lexington, KY |
| Congressional District Code: | 6 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2019 - September 2023 |
| FY 2021 Funding Amount: | $232,064 |
| Total Award Amount (all years): |
$1,073,315 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Sepsis is a major health issues for public and for veterans. A recent study conducted in 118 VA hospitals showed that 4.1% of patients undergoing surgery developed postoperative sepsis. The mortality rate of sepsis is high, exceeding 30%, due to a lack of efficient therapy. A great barrier for sepsis therapy is that sepsis is a multi-factor disease, involving endotoxin from bacteria, dysregulated response in immune effector cells, all of which lead to cell damage and endothelial dysfunction, res... |