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Funded Project Details - FY2021

Project Number:

Title: Role of Skeletal Muscle Mitochondrial Supercomplexes in Exercise Intolerance
Principal Investigator:

Gaurav Choudhary

Location: Providence, RI
Congressional District Code: 2
Research Service: Clinical Science R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $200,500
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


ABSTRACT Pulmonary hypertension is associated with poor quality of life, impaired functional tolerance and limitation of physical activity. Despite optimal available therapy for PH, patients report fatigue, decreased functional capacity, and worsening quality of life. Exercise intolerance (i.e. reduced VO2 max) is associated with reduced skeletal muscle (SkM) mitochondrial function and cellular respiration. Recent studies have demonstrated that changes in organization of electron transport chain...

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