Role of Skeletal Muscle Mitochondrial Supercomplexes in Exercise Intolerance
Congressional District Code:
Clinical Science R&D
July 2019 -
FY 2021 Funding Amount:
Total Award Amount (all years):
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ABSTRACT Pulmonary hypertension is associated with poor quality of life, impaired functional tolerance and limitation of physical activity. Despite optimal available therapy for PH, patients report fatigue, decreased functional capacity, and worsening quality of life. Exercise intolerance (i.e. reduced VO2 max) is associated with reduced skeletal muscle (SkM) mitochondrial function and cellular respiration. Recent studies have demonstrated that changes in organization of electron transport chain...