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Project Number: | I01BX004269-01A1 |
| Title: | Attenuation of Inflammatory Response in Progressive Neurodegeneration in Parkinson's Disease |
| Principal Investigator: | Naren Banik |
| Location: | Charleston, SC |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2019 - March 2023 |
| FY 2021 Funding Amount: | $240,495 |
| Total Award Amount (all years): |
$1,249,140 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Parkinson's disease (PD), a progressive degenerative disorder, affects almost 80,000 Veterans. Since there is no cure, new therapies must be developed to halt disease progression. While the mechanisms of this degen- erative process remain elusive, chronic inflammation may be involved. Calpain activates microglia and T cells, induces T cell migration/chemotaxis, plays a pivotal role in spinal cord (SC) degeneration, and may be a driver of inflammation and disease progression. Preliminary data fro... |