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Project Number: | I01BX004314-01A1 |
| Title: | Novel adrenergic mechanisms in heart failure therapy |
| Principal Investigator: | John R. Teerlink |
| Location: | San Francisco, CA |
| Congressional District Code: | 12 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2018 - September 2022 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$722,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Heart failure (HF) is a major clinical problem, with 1 million new cases per year, 1 million annual hospital admissions, a 50% 5-year mortality, and a role in 1 of 8 deaths. Little improvement in these statistics over recent decades indicates that current HF drugs could be improved. A classic feature of HF is elevation of cardiac sympathetic activity and circulating catecholamines, norepinephrine (NE) and epinephrine (EPI). NE and EPI activate 3 types of adrenergic receptors (ARs) on cardiac my... |