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Funded Project Details - FY2021

Project Number:

Title: Novel adrenergic mechanisms in heart failure therapy
Principal Investigator:

John R. Teerlink

Location: San Francisco, CA
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Heart failure (HF) is a major clinical problem, with 1 million new cases per year, 1 million annual hospital admissions, a 50% 5-year mortality, and a role in 1 of 8 deaths. Little improvement in these statistics over recent decades indicates that current HF drugs could be improved. A classic feature of HF is elevation of cardiac sympathetic activity and circulating catecholamines, norepinephrine (NE) and epinephrine (EPI). NE and EPI activate 3 types of adrenergic receptors (ARs) on cardiac my...

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