Megalin, mitochondrial intracrine signaling and the kidney
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Biomedical Laboratory R&D
January 2019 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Mitochondrial dysfunction and reactive oxygen species (ROS) play critical roles in disease processes from ischemic AKI, to immune response and inflammation, diabetes, obesity, metabolic syndrome, aging, neurodegenerative and cardiovascular diseases. Therefore, elucidating mechanisms of mitochondrial dysfunction is key to understanding the pathophysiology of many disease processes. Using the ischemia/reperfusion (I/R) kidney injury model to characterize mitochondrial pathways for kidney protectio...