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Project Number: | I01BX004127-01A2 |
| Title: | Alcohol-sensitized macrophages enhance colorectal carcinoma metastasis in the liver |
| Principal Investigator: | Benita L. McVicker |
| Location: | Omaha, NE |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2019 - December 2022 |
| FY 2021 Funding Amount: | $313,847 |
| Total Award Amount (all years): |
$1,501,595 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The liver is the terminal site of metastatic disease of colorectal cancer (CRC), that without intervention usually heralds death. The liver is also the main organ affected by alcohol consumption. Interestingly, alcohol use has been identified as a significant risk factor for colorectal liver metastasis (CRLM), yet contributing mechanisms remain undefined. Although alcohol-related CRLM is a serious health concern for the general population, the Veteran population is especially vulnerable because... |