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Project Number: | I01CX001777-08 |
| Title: | Assessing the role of metabolism in monocyte to macrophage differentiation in pulmonary fibrosis |
| Principal Investigator: | G. R.Scott Budinger |
| Location: | Chicago, IL |
| Congressional District Code: | 7 |
| Research Service: | Clinical Science R&D |
| Project Period: | October 2018 - September 2022 |
| FY 2021 Funding Amount: | $165,000 |
| Total Award Amount (all years): |
$735,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Project Summary Idiopathic Pulmonary Fibrosis (IPF) has a prognosis worse than most cancers, with only 20-30 percent of patients surviving 5 years after diagnosis. The pathophysiology in IPF relates to dysregulated repair after injury to the alveolo-capillary though the mechanisms that link alveolar capillary membrane injury with fibroblast activation and disordered repair are incompletely understood. In a recent publication we provide clear genetic evidence that alveolar macrophages are key eff... |