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Project Number: | I01BX001777-05A1 |
| Title: | Oxygen, Pulmonary Innate Immunity and Alveolar Epithelial Cell GM-CSF |
| Principal Investigator: | Robert Paine |
| Location: | Salt Lake City, UT |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2018 - June 2022 |
| FY 2021 Funding Amount: | $156,668 |
| Total Award Amount (all years): |
$696,227 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Pulmonary innate immune responses depend upon a highly regulated multicellular network to defend an enormous surface area of interaction with the external world. Disruption of these responses renders the host susceptible to pneumonia and subsequent systemic spread of infection. This proposal is to investigate the impact of local variation in oxygenation within the lung on key aspects of this host defense network. Heterogeneous ventilation is a common feature of many pulmonary conditions, includi... |