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Project Number: | I01BX004113-01A1 |
| Title: | MicroRNAs regulating plasma LDL and HDL |
| Principal Investigator: | Mahmood M Hussain |
| Location: | Brooklyn, NY |
| Congressional District Code: | 11 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2018 - June 2022 |
| FY 2021 Funding Amount: | $233,334 |
| Total Award Amount (all years): |
$1,104,616 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Plasma high LDL and low HDL cholesterol levels are risk factors for cardiovascular diseases. MicroRNAs (miRs), small non-coding endogenous RNAs, target multiple pathways and regulate physiologic functions. Because miRs modulate diverse biological pathways, we hypothesized that miRs exist in nature that might simultaneously lower LDL and increase HDL. To discover them, we screened a human miRs library and identified miR-1200 that decreased apoB (LDL scaffold protein) and increased apoAI (major HD... |