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Project Number: | I01BX002046-05A1 |
| Title: | Targeting Microvascular Contributors to Impaired Functional Exercise Capacity in Diabetes |
| Principal Investigator: | Jane E.B. Reusch |
| Location: | Denver, CO |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2018 - March 2022 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$771,300 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Diabetes (DM) shortens lifespan, an impact that is not fully explained by traditional cardiovascular (CV) risk factors. Functional Exercise Capacity (FEC) is a universal predictor of CV and all-cause mortality and it is decreased in people with diabetes. The overall goal of our combined basic and clinical research program is to understand and treat impaired FEC in DM to prevent premature mortality. New data from our lab indicate that: Oxygen delivery uniquely limits in vivo muscle mitochondrial... |