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Project Number: | I01BX000152-08 |
| Title: | MECHANISMS AND REGULATION OF INTESTINAL CHOLESTEROL TRANSPORT |
| Principal Investigator: | Waddah Alrefai |
| Location: | Chicago, IL |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2018 - June 2022 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$781,068 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Niemann-Pick C1-Like 1, NPC1L1, is crucial for cholesterol absorption and is the molecular target for ezetimibe, the cholesterol lowering drug. Previous studies showed that NPC1L1 expression is increased in patients with diabetes mellitus contributing to associated hypercholesterolemia. Blocking choelsterol absoprtion with ezetimibe in combination with statins (inhibitors of cholesterol synthesis) has been shown to be more effective than treatment with statins alone in lowering serum cholesterol... |