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Project Number: | I01BX003850-01A2 |
| Title: | DNA Binding of Human and Viral Transcription Factors is Associated with Rheumatoid Arthritis Risk Loci |
| Principal Investigator: | Kenneth M Kaufman |
| Location: | Cincinnati, OH |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2018 - September 2022 |
| FY 2021 Funding Amount: | $258,524 |
| Total Award Amount (all years): |
$1,208,815 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: This Merit Review application is based on our hypotheses that Fibroblast-Like Synoviocytes (FLS) from Rheumatoid Arthritis (RA) patients infected with Epstein - Barr virus (EBV) will have unique gene expression properties that alter the host immune response to EBV, and that these difference influences the risk for developing RA. These hypotheses is based on the following observations: All 12 of the FLS cell lines that we have evaluated, six from Rheumatoid Arthritis (RA) patients and six from Os... |