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Funded Project Details - FY2021

Project Number:

Title: PTH receptor Signaling and Diabetes-induced Bone Disease
Principal Investigator:

Teresita Bellido

Location: Little Rock, AR
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Osteocytes play a critical role in bone homeostasis by regulating the production and activity of osteoblasts and osteoclasts; but less is known about osteocyte function in bone pathophysiology. Work by the PI during the previous funding period of this Merit award showed that activation of parathyroid hormone 1 receptor (PTH1R) signaling in osteocytes inhibits the expression of Sost/sclerostin, the osteocyte-derived inhibitor of bone formation, and increases in osteocytes the expression of RANKL,...

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