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Project Number: | I01BX002665-05 |
| Title: | Mechanisms of Resistance to mTOR Targeted Therapies |
| Principal Investigator: | Joseph F. Gera |
| Location: | Sepulveda, CA |
| Congressional District Code: | 33 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2018 - June 2022 |
| FY 2021 Funding Amount: | $346,389 |
| Total Award Amount (all years): |
$1,679,678 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The broad objective of this proposal is to investigate the intrinsic mechanisms of tumor cell resistance to newly developed mTOR inhibitors such that their future use may be optimized in the clinic. We have identified an alternate mechanism of mRNA translation initiation that is activated upon mTOR inhibitor exposure allowing tumor cell survival in the face of global inhibition of protein synthesis. These experiments will delineate the molecular mechanisms promoting activation of this salvage pa... |