Interaction of GCSF with the Endocannabinoid System in Promoting Brain Repair
Congressional District Code:
Biomedical Laboratory R&D
October 2018 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Background: G-CSF has been identified as a potential therapeutic agent for TBI. Administration of G- CSF soon after injury results in proliferation and release into the circulation of bone marrow-derived cells (BMDC). Monocytes from blood are recruited into the brain to the site of the lesion where they differentiate into microglia. These, in turn generate a number of neurotrophic factors and cytokines involved in repair and regenerative processes. Numerous studies indicate that TBI impacts the...