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Project Number: | I01BX004037-01A1 |
| Title: | Interaction of GCSF with the Endocannabinoid System in Promoting Brain Repair |
| Principal Investigator: | Shijie Song |
| Location: | Tampa, FL |
| Congressional District Code: | 14 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2018 - September 2023 |
| FY 2023 Funding Amount: | $217,276 |
| Total Award Amount (all years): |
$1,440,995 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Background: G-CSF has been identified as a potential therapeutic agent for TBI. Administration of G- CSF soon after injury results in proliferation and release into the circulation of bone marrow-derived cells (BMDC). Monocytes from blood are recruited into the brain to the site of the lesion where they differentiate into microglia. These, in turn generate a number of neurotrophic factors and cytokines involved in repair and regenerative processes. Numerous studies indicate that TBI impacts the... |