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Project Number: | I01CX001631-01A2 |
| Title: | Pathogenesis and Treatment of AA Amyloidosis |
| Principal Investigator: | Merrill D. Benson |
| Location: | Indianapolis, IN |
| Congressional District Code: | 7 |
| Research Service: | Clinical Science R&D |
| Project Period: | July 2018 - June 2022 |
| FY 2021 Funding Amount: | $165,000 |
| Total Award Amount (all years): |
$741,250 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: AA (secondary, reactive) amyloidosis is a disease caused by extracellular deposition of insoluble β-pleated sheet fibrils composed of amyloid A (AA) protein, an N-terminal fragment of the acute phase protein serum amyloid A (SAA). The deposits disrupt tissue structure and eventually compromise organ function. Common sites of deposition include kidney, spleen, liver, and intestine. In humans proteinuria due to glomerular deposits is often the first clinical manifestation, and with increasing depo... |