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Project Number: | I01CX001211-05 |
| Title: | Role of Gut Microbial Translocation in Initiating Autoimmunity |
| Principal Investigator: | Gary S. Gilkeson |
| Location: | Charleston, SC |
| Congressional District Code: | 1 |
| Research Service: | Clinical Science R&D |
| Project Period: | January 2019 - December 2022 |
| FY 2021 Funding Amount: | $165,000 |
| Total Award Amount (all years): |
$765,350 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Genetic and environmental factors contribute to systemic lupus erythematosus (SLE). Previous studies showed environmental factors such as bacterial products or their-induced inflammatory mediators (e.g., IFN-α) are involved in SLE pathogenesis. Previous studies from others and we revealed that multiple autoAbs are more commonly detected in first-degree relatives of lupus patients (FDRs), compared to unrelated healthy controls (UHCs). In addition, FDRs have heightened levels of inflammation (e.g.... |