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Funded Project Details - FY2021

Project Number:

Title: The Role of Bone Marrow Derived Eicosanoids in Renal Disease Progression
Principal Investigator:

John Montford

Location: Denver, CO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2023
FY 2021 Funding Amount: $277,068
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Eicosanoids are biologically active products of phospholipid metabolism which are involved in the pathogenesis of numerous autoimmune and inflammatory diseases in humans. Published data has implicated that eicosanoids derived from the microsomal Prostaglandin Synthase type 1 (mPGES-1) and 15-Lipoxygenase (12/15-LOX) enzymes are involved in mediating tissue injury in multiple different cell types including epithelial cells and bone marrow derived monocytes (BMDMs). Of note, mPGES-1 and 12/15-LOX...

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