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Project Number: | I01BX003440-01A2 |
| Title: | A novel estrogen modulator for the treatment of Alzheimer's disease |
| Principal Investigator: | Joseph F. Quinn |
| Location: | Portland, OR |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2018 - March 2022 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$721,686 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: A number of studies have shown that the sex hormone, estrogen, has favorable or “neurotrophic” effects on neuronal cells in the brain. Unfortunately, clinical trials using estrogen revealed unacceptable side effects, including increased risk of blood clots and hormone- sensitive cancers. Moreover, estrogen is not practical for use in men, because it promotes unwanted physical changes and feminizing effects; consequently, estrogen has been abandoned as a treatment for AD. As an alterative strateg... |