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Funded Project Details - FY2021




Project Number:

I01BX002771-01A2
Title: Cyclophilin-D: A Regulator of Mitochondrial Oxidative Phosphorylation
Principal Investigator:

Raul J. Gazmuri

Location: Hines, IL
Congressional District Code: 10
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2021
FY 2021 Funding Amount: $156,288
Total Award Amount
(all years):
$772,722
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Cyclophilin-D (Cyp-D) is a peptidyl prolyl isomerase which catalyzes the cis-trans isomerization of peptidyl prolyl bonds and thereby regulates conformational changes of target proteins. Cyp-D is the only cyclophilin res- ident in mitochondria, and until recently it was best known for its effect on the mitochondrial permeability transi- tion pore. We recently discovered that Cyp-D interacts with two of the three mitochondrial transcription factors (i.e., TFB1M and TFB2M but not TFAM) and subsequ...



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