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Funded Project Details - FY2021

Project Number:

Title: Pathogenesis of sepsis-induced dysfunction of innate immunity
Principal Investigator:

Xiao-Di Tan

Location: Chicago, IL
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $267,634
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Our long-term goal is to study molecular mechanisms underlying pathogenesis of sepsis, a potentially life-threatening illness caused by severe traumatic injury and trauma infections. Sepsis is the most costly condition for VA hospitals to treat. When sepsis becomes severe, it has a high mortality rate even with appropriate care. Sepsis is associated with overwhelming inflammatory response and dysregulation of innate immunity, which can lead to persistent inflammation and multiple organ failure....

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