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Project Number: | I01BX003415-01A1 |
| Title: | Harnessing the Autophagy-Lysosomal Biogenesis Response in Macrophages to Treat Atherosclerosis |
| Principal Investigator: | Babak Razani |
| Location: | St Louis, MO |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2018 - December 2021 |
| FY 2021 Funding Amount: | $122,800 |
| Total Award Amount (all years): |
$692,913 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Atherosclerosis is the underlying cause of the majority of cardiovascular diseases including myocardial infarction, strokes, and heart failure leading to tremendous morbidity and mortality worldwide. Risk factor modification such as reductions in hyperlipidemia and hypertension constitute the only treatment strategy available for this vexing disease. Thus, there is an active effort to identify the culprit cellular processes that provide mechanistic insight. Reports of the pro-atherogenic phenoty... |