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Project Number: | I01BX001324-06A1 |
| Title: | Impairment and recovery of CD4 T cell-dependent B cell responses after sepsis |
| Principal Investigator: | Thomas S Griffith |
| Location: | Minneapolis, MN |
| Congressional District Code: | 5 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2018 - December 2021 |
| FY 2021 Funding Amount: | $256,603 |
| Total Award Amount (all years): |
$1,200,732 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Sepsis causes more deaths in U.S. hospitals annually than prostate cancer, breast cancer, and AIDS combined. Elderly patients are a particularly high-risk group, with an incidence rate of ~60% of all septic cases. The elderly are also extremely vulnerable to the consequences of sepsis, showing 100-fold higher mortality than younger patients. Some of these deaths occur acutely after sepsis, but ~70% of these patients survive the initial infection, and succumb to opportunistic infections during th... |