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Funded Project Details - FY2021

Project Number:

Title: Engineered T Cells Targeting Abnormal Glycans in Metastatic Prostate Cancer
Principal Investigator:

Avery D Posey

Location: Philadelphia, PA
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2022
FY 2021 Funding Amount: $178,372
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


1. Objective(s): This proposal aims to profile abnormal glycosylation in prostate tumors of veterans, to determine if engineered chimeric antigen receptor (CAR) T cells targeting abnormally glycosylated proteins will demonstrate efficacy against bone-metastatic prostate cancer, and to evaluate mechanisms to improve T cell trafficking to tumor sites and enhance resistance to immunosuppression. 2. Research Design: De-identified veteran prostate cancers will be assembled into tumor tissue microarra...

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