Role of ryanodine receptor dysfunction after spinal cord injury
Congressional District Code:
October 2017 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Muscles paralyzed by spinal cord injury (SCI) atrophy extensively, are weaker, fatigue more quickly and generate lower specific tension (force produced per unit of cross-sectional area), such that they generate less force in response to maximal motor neuron activation. For individuals with motor-incomplete lesions, interventions that improve specific force and/or fatigue resistance would be obvious opportunities to improve function. A newly recognized cause of impaired specific force production...