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Project Number: | I01CX001610-01 |
| Title: | Failure of the glutamate uptake-ascorbic acid exchange drives seizure susceptibility and severity |
| Principal Investigator: | James M. May |
| Location: | Nashville, TN |
| Congressional District Code: | 5 |
| Research Service: | Clinical Science R&D |
| Project Period: | April 2017 - September 2021 |
| FY 2021 Funding Amount: | $82,500 |
| Total Award Amount (all years): |
$686,990 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Co-occurrence of seizures with Alzheimer's disease dramatically alters prognosis, and speeds cognitive de- cline. Even mild seizures that may go undetected by caregivers can increase Alzheimer's disease pathogene- sis and also independently lead to neurodegeneration and cognitive dysfunction. Subclinical (non-scorbutic) vitamin C (ascorbate) deficiency is widespread in the USA, particularly among the elderly, and veteran popula- tions where smoking and oxidative stress-related diseases such as a... |