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Project Number: | IK6BX003782-01 |
| Title: | BLR&D Research Career Scientist Award |
| Principal Investigator: | K. H. William Lau |
| Location: | Loma Linda, CA |
| Congressional District Code: | 31 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2017 - March 2022 |
| FY 2021 Funding Amount: | $236,500 |
| Total Award Amount (all years): |
$1,133,151 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The current research focus of the nominee is two-fold: The first is to delineate a unique molecular mechanism regulating functional activity of osteoclasts that involves negative regulation of the expression of a distinctive osteoclastic protein-tyrosine phosphatase (PTP-oc), which is a potent activator of functional activity of mature osteoclasts, by microRNA-17 (miR17). This project is supported by a BLR&D Merit Review award and seeks to test 3 hypotheses: 1) resorption cytokines activates ost... |