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Project Number: | I01BX003487-01A2 |
| Title: | Elucidating the Mechanisms that link the Shared Epitope, Periodontal Disease and Arthritis |
| Principal Investigator: | David D. Brand |
| Location: | Memphis, TN |
| Congressional District Code: | 9 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2017 - March 2021 |
| FY 2021 Funding Amount: | $243,778 |
| Total Award Amount (all years): |
$1,445,129 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Periodontal disease (PD) and Rheumatoid Arthritis (RA) have many features in common. PD is a chronic inflammatory disease of the periodontium, the soft and hard tissues supporting the teeth, and is characterized by the destruction of the alveolar bone as a result of the chronic bacterial challenge and a compromised immune response. RA is a chronic inflammatory disease of the diarthrodial joints which results in reduced mobility. Both diseases exhibit a strong genetic component, the “shared epitope... |