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Project Number: | I01BX001968-05A1 |
| Title: | Regulation of hepatic gene expression and metabolism by FoxO proteins |
| Principal Investigator: | Terry G. Unterman |
| Location: | Chicago, IL |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2017 - March 2022 |
| FY 2021 Funding Amount: | $8,118 |
| Total Award Amount (all years): |
$760,540 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Project Summary/Abstract Excessive production of glucose by the liver plays a central role in the development of diabetes, where the ability of insulin to regulate hepatic glucose production (HGP) is impaired. FoxO transcription factors are major targets of insulin and play an important role in mediating effects of insulin on multiple aspects of glucose and lipid metabolism in the liver, including gluconeogenesis, glycolysis and lipogenesis. However, the mechanisms by which FoxO proteins exert... |